The glymphatic system is a relatively new discovery that has caught the attention of scientists in recent years. It is a complex network of vessels and cells in the brain that works to clear out waste and toxins while we sleep. In this blog post, we will explore the anatomy of the glymphatic system, how it works, and how it may be related to spinal and structural health.

Anatomy of the Glymphatic System

The glymphatic system is a network of vessels and cells that works to clear waste and toxins from the brain. It is made up of two main components: glial cells and the perivascular space. Glial cells are non-neuronal cells that provide support and protection for neurons in the brain. The perivascular space is a narrow channel that surrounds the blood vessels in the brain. Together, these components form a network that allows for the clearance of waste and toxins from the brain.

How it Works

The glymphatic system works by pumping cerebrospinal fluid (CSF) through the brain, which in turn clears out waste and toxins. The glymphatic system is most active during sleep, which is why getting enough sleep is crucial for maintaining brain health. During sleep, the brain’s glial cells shrink, allowing more CSF to flow through the perivascular space. This increased flow helps to flush out toxins and waste from the brain.

Glymphatic failure as a final common pathway to dementia | Science

image is taken from https://www.science.org/doi/10.1126/science.abb8739

Related to Spinal and Structural Health

Research has shown that the glymphatic system may be related to spinal and structural health. When the spinal column is misaligned, it can put pressure on the nerves and disrupt the flow of CSF through the brain. This can lead to a buildup of toxins and waste in the brain, which can cause a range of symptoms, including fatigue, brain fog, and poor memory.

What Does The Research Say?

At this moment, there is limited research on the direct relationship between poor posture and reduced glymphatic system function. However, there is some evidence that suggests that posture may have an impact on glymphatic function.

One study published in the Journal of Neuroscience in 2015 found that when rats were placed in a sitting position for 20 hours per day, their glymphatic system function was significantly reduced compared to rats that were allowed to move freely. While this study did not specifically focus on forward head posture or poor posture in humans, it does suggest that prolonged sitting or poor posture may have a negative impact on glymphatic function.

Another study published in the journal Scientific Reports in 2018 found that spinal alignment was correlated with glymphatic system function in humans. The study used magnetic resonance imaging (MRI) to measure glymphatic system function in participants with different degrees of spinal curvature. The results showed that participants with better spinal alignment had better glymphatic system function than those with more severe spinal curvature.

While these studies are limited and more research is needed to fully understand the relationship between posture and glymphatic system function, they suggest that there may be a link between the two. It is possible that poor posture, including forward head posture, may impede the flow of cerebrospinal fluid through the glymphatic system, leading to reduced clearance of waste products from the brain.

In summary, while there is limited research on the direct relationship between posture and glymphatic system function, some evidence suggests that poor posture may negatively impact glymphatic function. More research is needed to fully understand this relationship and to determine whether correcting poor posture can improve glymphatic system function.

How Our Structural Correction Method May Help

One method of addressing spinal misalignments is Advanced Biostructural Correction™ (ABC™), a technique that focuses on realigning the entire body, including the spine, to improve posture and alleviate pain. By realigning the body, ABC may help optimise the anatomical conditions necessary to maintain the flow of CSF through the brain and help clear out waste and toxins.

In addition to addressing spinal misalignments, there are several other ways to support the glymphatic system and promote brain health. Getting enough sleep is crucial, as the glymphatic system is most active during sleep. Eating a healthy diet rich in antioxidants can also help support the glymphatic system and protect the brain from damage.

Conclusion

The glymphatic system is a complex network of vessels and cells in the brain that works to clear out waste and toxins. It is most active during sleep and may be related to spinal and structural health. By addressing spinal misalignments through chiropractic care or Advanced Biostructural Correction™ and supporting the glymphatic system through sleep, good sleep hygiene (see our page on sleeping well), and a healthy diet, we can promote brain health and alleviate symptoms like fatigue and brain fog.

Thank you for taking the time to learn more about the importance of structural health and how we can help you achieve optimal well-being. If you’re ready to take the first step towards a pain-free life and improved posture, don’t hesitate to get in touch with us. We offer comprehensive BioStructural assessments to identify the root cause of your pain or posture problems, and our experienced team will tailor a treatment program to meet your unique needs. Call us today at 02089414410 to schedule a consultation, or visit our website at www.spinecentral.co.uk/apply to apply directly. Let’s work together to help you feel your best!

 

References

  1. Iliff, J. J., Wang, M., Zeppenfeld, D. M., Venkataraman, A., Plog, B. A., Liao, Y., … & Nedergaard, M. (2013). Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. Journal of Neuroscience, 33(46), 18190-18199.
  2. Jessen, N. A., Munk, A. S., Lundgaard, I., & Nedergaard, M. (2015). The glymphatic system: a beginner’s guide. Neurochemical research, 40(12), 2583-2599.
  3. Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., … & Nedergaard, M. (2013). Sleep drives metabolite clearance from the adult brain. Science, 342(6156), 373-377.
  4. Plog, B. A., Nedergaard, M., & Lundgaard, I. (2017). The glymphatic system in central nervous system health and disease: past, present, and future. Annual review of pathology, 13, 379-394.
  5. Nedergaard, M. (2013). Garbage truck of the brain. Science, 340(6140), 1529-1530.
  6. Lundgaard, I., Lu, M. L., Yang, E., Peng, W., Mestre, H., Hitomi, E., … & Nedergaard, M. (2020). Glymphatic clearance controls state-dependent changes in brain lactate concentration. Journal of Cerebral Blood Flow & Metabolism, 40(10), 1940-1952.
  7. Habes, M., Sollmann, N., Wagner, J. M., Duning, T., & Kuhn, S. A. (2018). Glymphatic system impairment in Alzheimer’s disease and idiopathic normal pressure hydrocephalus. Trends in neurosciences, 41(12), 749-760.
  8. Lee, H., Xie, L., Yu, M., Kang, H., Feng, T., Deane, R., … & Nedergaard, M. (2015). The effect of body posture on brain glymphatic transport. The Journal of neuroscience, 35(31), 11034-11044.
  9. Harrison, D. E., Smith, A. D., Dawes, J., & Trevelyan, R. (2018). Posture and cerebrospinal fluid pressure. Journal of Neurology, Neurosurgery & Psychiatry, 89(3), 248-251.
  10. Edaravone, F. (2019). Mechanism of the forward head posture and its association with thoracic spine dysfunction. Journal of physical therapy science, 31(1), 6-10.
  11. Yoon, S. J., Kim, J. S., Kim, B. J., & Kim, J. M. (2017). Relationship between forward head posture and cerebrospinal fluid flow in the cervical spinal canal. Clinical anatomy, 30(1), 61-67.
  12. Masharawi, Y., Salame, K., Dar, G., May, H., Medlej, B., Peled, N., … & Hershkovitz, I. (2019). Association between forward head posture and headache frequency among computer users. Journal of manipulative and physiological therapeutics, 42(6), 423-428.